As the second week of the NFL season approaches, fantasy football enthusiasts are eager to know which running backs to trust. With injuries, new faces, and team dynamics in play, it's essential to reassess the landscape and identify the top performers. In this article, we'll dive into the top five must-start running backs for Week 2, highlighting the key factors that make them stand out.

But first, let's challenge the assumption that injuries are the only factor affecting a player's performance. What if a player's workload increases due to a teammate's absence? How might their role change, and what impact could this have on their fantasy value?

Now, let's get to the top five must-start running backs for Week 2:

1. Jonathan Taylor, Indianapolis Colts at Green Bay Packers

Taylor's Week 1 performance was underwhelming, but don't write him off just yet. With the Packers' struggles to stop the run, Taylor is poised for a breakout game. He'll likely see at least 20 touches and has a high ceiling for scoring.

2. De'Von Achane, Miami Dolphins vs. Buffalo Bills

Achane's ankle injury is a concern, but if he's cleared to play, he's a top-three option. The Bills' porous run defense makes him a prime candidate for a big game.

3. Josh Jacobs, Green Bay Packers vs. Indianapolis Colts

Jacobs is a workhorse back who thrives in favorable matchups. With Jordan Love out, the Packers may rely more on the run, making Jacobs an attractive option.

4. Tony Pollard, Tennessee Titans vs. New York Jets

Pollard's dominant performance in Week 1 sets him up for success in Week 2. The Jets struggled to contain the 49ers' running backs, and Pollard is likely to see a significant workload.

5. Najee Harris, Pittsburgh Steelers at Denver Broncos

Harris is a solid RB2 option, and this week's matchup against the Broncos makes him an attractive play. The Broncos' run defense was vulnerable last season, and Harris could capitalize on this trend.

Fantasy Football: Unlock the Top Running Backs for Week 2

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