Brittle bone disorders, or FBDs, can cause people to break bones easily. Scientists are trying to figure out which genes are responsible for these conditions. One way they are doing this is by studying zebrafish. These tiny fish share many bone-building genes with humans. Researchers used a tool called CRISPR to mess with the genes in zebrafish embryos and see how it affected their bones. Six genes linked to severe bone diseases and four genes associated with bone strength were tested. After looking at the fish bones under a microscope and using a special dye that highlights bone, they found that some fish had messed-up bones, like broken spines and strange shapes. They also found that some fish died early because of these bone problems. Listening to some of the bone-making messages inside the fish cells, they noticed some were different in the fish with bone issues. This shows that zebrafish can help scientists figure out which genes are important for building healthy bones in humans.
