How Bacteria Like Salmonella Use Sirtuins to Stay Ahead

Ever wondered how bacteria stay alive inside your body? Salmonella, for one, has a clever trick up its sleeve. It uses two special enzymes, SIRT1 and SIRT3, to mess with your body's energy system. You might know these enzymes as sirtuins. They're like the body's metabolic regulators, helping to control how cells use energy. Scientists found that when Salmonella jumps into your cells, it starts controlling these sirtuins to keep its own energy high and your body's energy low. This way, it can grow and hide from your immune system. Kind of like a sneaky roommate who eats all your food and leaves you with the crumbs! The problem is, when you try to stop these sirtuins from helping Salmonella, bad things happen. The bacteria can't grow as well in your cells, but in mice, it spreads even more, causing more harm. It's like trying to stop a thief by making them stronger, but instead, they just become stealthier. SIRT1 and SIRT3 also change your body's immune cells, making them less inflamed and more friendly to Salmonella. They do this by changing how certain proteins work, like p65 NF-κB and HIF-1α. So, these clever bacteria use your own body's tools to stay alive and cause havoc. But don't worry, scientists are working on finding new ways to stop this sneaky trick!

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