Light Therapy: Unraveling the Secret to Healthy Hair Cells

Hair loss can be a real bummer, and many people turn to medicine like Minoxidil and Finasteride to help. But these drugs can have side effects that make people stop using them. That's where photobiomodulation (PBM) comes in. It's safe and non-invasive, making it a promising alternative. Scientists wanted to know how PBM affects the hair cells, called dermal papilla cells (DPCs), that make our hair grow. They tested two types of light: continuous wave (CW) and pulsed wave (PW). For CW, the best results were seen with an irradiance of 8 mW/cm² and a dose of 8 J/cm². For PW, the sweet spot was a peak irradiance of 10 mW/cm², a duty cycle of 80%, a frequency of 500 Hz, and a dose of 8. 8 J/cm². Surprisingly, PBM turned out to be a great way to boost cell viability, proliferation, and migration in DPCs, especially when using PW. It does this by messing with the Wnt/β-Catenin and Transforming Growth Factor signaling pathways. This study shows that the right light conditions can make PBM super effective, and pulsed light might just be the future of treating hair loss.

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