New Hope for Kidney Disease: The Promise of ARNIs

The Promise of ARNIs

ARNIs, or Angiotensin Receptor-Neprilysin Inhibitors, are revolutionizing the treatment of heart failure. Now, researchers are exploring their potential for kidney disease.

How ARNIs Work

• Neprilysin is an enzyme that breaks down certain proteins in the body.
• ARNIs block neprilysin, which may help improve kidney function.
• Early studies suggest ARNIs can reduce protein in the urine, a positive indicator.
• They may also help with kidney scarring and blood vessel function.

Real-World Results

• UK HARP-III Study:
• Found ARNIs reduce protein in urine.
• Did not show a clear protective effect on kidneys (study design limitations).
• Real-world data:
• Shows ARNIs have an acceptable safety profile.
• Benefits outweigh risks, making them a potential new option for kidney disease.

The Future of ARNIs

• More studies are needed to determine the best use of ARNIs for kidney disease.
• Currently, they remain a promising but not yet fully proven treatment.