Week 10 of the NFL season is packed with some interesting matchups. Let's dive into the picks and predictions.

Falcons are favored over the Saints by 3. 5 points. The Falcons have been on a roll, winning four out of their last five games, while the Saints have struggled. Their new coach might spark a change, but it's likely the Falcons will come out on top. The Saints' run defense is especially weak, allowing the second-highest yards per carry (5. 1).

The Giants are favored by 6. 5 points over the Panthers. The Giants haven’t been favored to win since Week 2 but are ranked 23rd in DVOA, ahead of teams like Dallas and Cleveland. However, their run defense is the worst in the league, and they have the lowest red-zone touchdown percentage (40%). This makes it hard for them to cover a spread that requires them to score more than half the time they reach the red zone.

Broncos are underdogs by 8 points against the Chiefs. The Broncos have a solid pass rush, sacking the quarterback on 9. 75% of throws (third-best in the NFL). The undefeated Chiefs might have their eyes on next week's big game against the Bills, which could affect their focus this week.

Bills are favored by 4 points against the Colts. The Bills are one of the top teams in yards per play and yards per play allowed. They're well-coached on defense and can easily contain Joe Flacco, who will be missing his top receiver, Michael Pittman Jr.

49ers are favored by 6. 5 points over the Buccaneers. The 49ers have a strong defense, ranking second in pass defense. The Buccaneers are dealing with many injuries, including top receivers Chris Godwin, Mike Evans, and Jalen McMillan. The 49ers are also getting back Christian McCaffrey, tilting the scales even more.

Steelers are underdogs by 3 points against the Commanders. This is the first time Jayden Daniels faces a top-10 DVOA defense. The Commanders scored just 18 points against Chicago, which ranks 11th in defense, and six of those came from a Hail Mary. Mike Tomlin's team is unlikely to fall for such tricks.

Vikings are favored by 7 points against the Jaguars. The Jaguars' quarterback, Mac Jones, has struggled against blitzes, and the Vikings blitz more than any other team. The Vikings defense is one of the best in forcing turnover-worthy plays.

Patriots are underdogs by 6 points against the Bears. Neither team excels in this matchup. Chicago allows the fourth-highest yards per carry, and New England isn't great against the run either. Rhamondre Stevenson might help keep the game close.

Titans are underdogs by 7. 5 points against the Chargers. The Chargers have changed their game plan, focusing more on passing. The Titans have a solid defense, allowing the fewest yards per pass attempt. Expect a low-scoring game with a close finish.

Eagles are favored by 7 points over the Cowboys. With Cooper Rush starting for Dallas, the Eagles are a great bet. The line opened at +3, showing a point of value here.

Jets are favored by 1. 5 points over the Cardinals. Advanced analytics indicate this line is off, but sharps are backing the Jets. The Jets had extra time to prepare and are fighting to keep their season alive.

Texans are underdogs by 3. 5 points against the Lions. With Nico Collins likely to play, the Texans' offense gets a boost. The Texans' defense is also strong, ranking second in DVOA.

Rams are favored by 1. 5 points over the Dolphins. Both teams are dealing with injuries. Tyreek Hill is questionable, making it risky to bet on Miami without him.

NFL Week 10: Predictions and Picks Broken Down

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