The NFL Week 17 schedule is packed with exciting matchups. Let's dive into a few standouts. The Indianapolis Colts head to MetLife Stadium to face the New York Giants. Despite being the visitors, the Colts have a win under their belts at this venue, beating the Jets back in November. The Giants, however, have struggled at home with an 0-8 record. Injuries may also play a factor, with several Giants listed as questionable. Could this be a chance for the Colts to secure a win and end the Giants' home losing streak?

Meanwhile, the Buffalo Bills host the New York Jets. With the AFC No. 2 seed on the line, the Bills have a lot to play for. But can they cover a substantial spread? The Bills haven't covered large spreads consistently, and a win by just a few points would still secure their playoff spot.

In another intriguing matchup, the Los Angeles Chargers visit the New England Patriots. A win here would clinch a wild-card spot for the Chargers. Despite a tough loss to the Bucs, the Chargers rebounded quickly, defeating the Broncos just a few days later. Can they continue this momentum and secure their playoff berth?

The Denver Broncos, fresh off a Thursday night game, take on the Cincinnati Bengals. The Broncos have been red-hot lately, scoring points in bunches. With no major injuries, they look like a strong underdog pick against a Bengals defense that's allowed plenty of points this season.

Saturday also brings us the Arizona Cardinals battling the Los Angeles Rams. Although the Rams are vying for the NFC West title, the Cardinals have shown they can keep games close. In a primetime spot, can they pull off an upset?

On Sunday, the Las Vegas Raiders face the New Orleans Saints. With the Raiders out of the top pick conversation, they might be playing more freely. And with a healthier offense, they could outscore the Saints, who have been struggling.

The Tennessee Titans seek revenge against the Jacksonville Jaguars. Since Mac Jones took over, the Titans have struggled, but Mason Rudolph has brought a spark, averaging 28. 5 points in his recent starts.

In a crucial NFC East matchup, the Philadelphia Eagles host the Dallas Cowboys. The Eagles are still in the running for the top seed but are missing key players due to injury. How will this impact their ability to cover a large spread against a Cowboys team playing well?

The Carolina Panthers face the Tampa Bay Buccaneers, who have been going through some ups and downs. Despite the Panthers' recent success against the spread, the Buccaneers' intensity could be too much for them to handle.

Finally, the Miami Dolphins travel to Cleveland to play the Browns. With a wet forecast favoring the Dolphins, can they cover a sizeable spread against a Browns team that's been losing by large margins?

Best bets for the week include the Lions, Colts, and Chargers. Don't forget to check out the betting insights from our expert, who has a proven track record in NFL handicapping.

Pick’em Predictions: Can Colts Beat Giants at Home?

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