The Power of Stable Surfactants in Keeping Biopharmaceuticals Fresh

Biopharmaceuticals are on the rise, but they have a big problem—they tend to clump together quickly. Right now, we use surfactants like polysorbates and poloxamers to stop this from happening and make them last longer. However, these surfactants aren't very stable themselves. They change into many different compounds over time, and some of these can cause serious side effects in patients. Scientists have now found a way to use a different kind of surfactant—polyacrylamide-derived ones—to figure out how surfactants really help protect proteins. By making a library of these surfactants with the same composition but different structures, they discovered a new property called compositional dispersity. This property is crucial for how well the surfactant works. With this understanding, they designed new, ultra-stable surfactants that can increase the stability of tricky proteins like monomeric insulin by ten times! This is a big deal because it means we can finally move away from guesswork and start designing these protective coatings in a smart way.

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