TWEAK/Fn14: A Double-Edged Sword in Skin Health and Healing

Overview

The TWEAK/Fn14 pathway is a critical system in our bodies that regulates cell growth, movement, and transformation. It belongs to the TNF superfamily, acting like a molecular switch for various cellular processes.

Role in Skin Health

Healing and Damage

• Healing: Assists in wound repair.
• Damage: Excessive activity can lead to harm.

Skin Diseases

• Active in: Lupus, psoriasis, and skin cancer.
• Functions: Promotes new blood vessel formation and inflammation.

Impact on Stem Cells

• Growth and Transformation: Controls how stem cells develop into different cell types.
• Importance: Crucial for tissue healing and repair.

Medical Potential

• Early Disease Detection: Could help identify diseases early.
• New Treatments: May lead to innovative therapies.
• Ongoing Research: Scientists are exploring its roles in skin diseases and stem cell therapy.