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Week 13 NFL Matchups: Who's Got the Edge?
USAFriday, November 28, 2025
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The NFL's Week 13 lineup is packed with exciting matchups, and experts have weighed in with their predictions. Let's dive into some of the key games and see who they think will come out on top.
Chicago Bears vs. Philadelphia Eagles
- Expert: Pete Prisco
- Prediction: Eagles win 30-21
- Key Points:
- Eagles' strong defense expected to force turnovers from rookie QB Caleb Williams.
- Saquon Barkley to get more touches, helping Eagles bounce back from recent loss to Cowboys.
Arizona Cardinals vs. Tampa Bay Buccaneers
- Expert: Pete Prisco
- Prediction: Buccaneers win and cover the spread
- Key Points:
- Buccaneers' backup QB Teddy Bridgewater steps in for injured Baker Mayfield.
- Cardinals' struggling offense vs. Buccaneers' defense expected to bounce back.
Atlanta Falcons vs. New York Jets
- Expert: Pete Prisco
- Prediction: Jets win and cover the spread
- Key Points:
- Low-scoring game expected due to strong defenses.
- Jets pull off upset at home with a 2.5-point advantage.
Houston Texans vs. Indianapolis Colts
- Expert: John Breech
- Prediction: Texans win 19-16
- Key Points:
- Texans' top-ranked defense to give Colts' offense a tough time.
- Close game predicted with Texans pulling off the upset.
Jacksonville Jaguars vs. Tennessee Titans
- Expert: Pete Prisco
- Prediction: Jaguars win late, Titans cover the spread
- Key Points:
- Jaguars on the road for second consecutive week.
- Titans expected to cover the spread but Jaguars pull it out late.
Los Angeles Rams vs. Carolina Panthers
- Expert: Pete Prisco
- Prediction: Rams win, Panthers cover the spread
- Key Points:
- Rams expected to win but Panthers' defense keeps them in the game.
- Panthers cover the spread with a 10.5-point disadvantage.
New Orleans Saints vs. Miami Dolphins
- Expert: Pete Prisco
- Prediction: Dolphins win 6 points
- Key Points:
- Dolphins' strong running game and improved defense key to covering the spread.
San Francisco 49ers vs. Cleveland Browns
- Expert: Tyler Sullivan
- Prediction: Browns cover the spread
- Key Points:
- Browns' dominant defense to give 49ers' QB Brock Purdy a tough time.
- Browns cover the spread with a 6-point disadvantage.
Minnesota Vikings vs. Seattle Seahawks
- Expert: Pete Prisco
- Prediction: Seahawks dominate
- Key Points:
- Seahawks' strong defense and Vikings' quarterback struggles key to big win.
Buffalo Bills vs. Pittsburgh Steelers
- Expert: Jordan Dajani
- Prediction: Bills cover the spread, win by a field goal
- Key Points:
- QB Josh Allen's ability to bounce back crucial for Bills.
Las Vegas Raiders vs. Los Angeles Chargers
- Expert: Tyler Sullivan
- Prediction: Raiders cover the spread, win by a touchdown
- Key Points:
- Raiders' strong pass rush and Chargers' offensive struggles key to close game.
Denver Broncos vs. Washington Commanders
- Expert: Jared Dublin
- Prediction: Broncos win 6.5 points
- Key Points:
- Broncos' strong defense too much for Commanders' backup quarterback.
denver broncospittsburgh steelersbuffalo billsminnesota vikingsmiami dolphinsnew orleans saintsjacksonville jaguarsnflindianapolis coltshouston texansatlanta falconsarizona cardinalschicago bearswashingtonlos angeleslasseattleclevelandsan franciscotennesseenew yorktampa bayphiladelphiajared dublinjosh allenjordanbrocktyler sullivancarolinajohn breechteddy bridgewaterbaker mayfieldcaleb williamspete prisco
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