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Week 2 NFL Bets: Smart Picks and Bold Predictions

USA, Las VegasThursday, September 11, 2025
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Week 1 left bettors scratching their heads, but Week 2 brings new opportunities.

Standout Bets to Consider

Buffalo Bills vs. New York Jets

  • Bills heavy favorites, but Jets' offense showed promise in Week 1.
  • Jets at home and a full touchdown underdog: Solid bet to cover the spread.

Philadelphia Eagles vs. Kansas City Chiefs

  • Eagles' offense struggled in Week 1, but Chiefs' defense has concerns.
  • High total points expected: Betting the under might be the way to go.

Los Angeles Rams vs. Tennessee Titans

  • Rams dealing with injuries on offensive line.
  • Titans' defense held Bo Nix to just 4 yards per attempt in Week 1.
  • Titans could be a live underdog.

Carolina Panthers vs. Arizona Cardinals

  • Cardinals' run game ranked seventh in EPA per rush in 2024.
  • Panthers' defense struggled against the run.
  • Cardinals are a solid bet to cover the spread.

Los Angeles Chargers vs. Las Vegas Raiders

  • Chargers' offense surprised in Week 1 with a pass-heavy attack.
  • Raiders' defense forced Drake Maye into one of his worst games.
  • Raiders are a solid bet to cover the spread.

Other Notable Games

Washington Commanders vs. Green Bay Packers

  • Packers dealing with injury questions on offensive line.
  • Packers are a solid bet to cover the spread.

Jacksonville Jaguars vs. Cincinnati Bengals

  • Total points expected are low, but anything under 50 points feels too low.

New York Giants vs. Dallas Cowboys

  • Cowboys looked better than expected in Week 1.
  • Giants looked worse than expected.
  • Cowboys are a solid bet to cover the spread.

Chicago Bears vs. Detroit Lions

  • Lions dealing with injuries on offensive line.
  • Bears are a solid bet to cover the spread.

New England Patriots vs. Miami Dolphins

  • Dolphins' offensive line in disarray.
  • This one is a pass.

San Francisco 49ers vs. New Orleans Saints

  • 49ers' defense impressed in Week 1.
  • 49ers are a solid bet to cover the spread.

Seattle Seahawks vs. Pittsburgh Steelers

  • Steelers dealing with injuries on offensive line.
  • Seahawks are a solid bet to cover the spread.

Cleveland Browns vs. Baltimore Ravens

  • Ravens are heavy favorites.
  • Ravens are a solid bet to cover the spread.

Atlanta Falcons vs. Minnesota Vikings

  • Vikings' defense is one of the best in the league.
  • Vikings are a solid bet to cover the spread.

Denver Broncos vs. Indianapolis Colts

  • Colts are dealing with injuries on offensive line.
  • Colts are a solid bet to cover the spread.

Tampa Bay Buccaneers vs. Houston Texans

  • Texans' defense is one of the best in the league.
  • Texans are a solid bet to cover the spread.

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