Week 18 of the NFL season is here, and it's time to make some picks! Let's break down the games and see what's in store.

The 49ers are without Brock Purdy, but they're still favored against the Cardinals. The Cardinals' run defense has been awful, so expect the 49ers to run the ball effectively. The Giants face the Eagles' backups and could pull off a win. The Packers should dominate the Bears, who have struggled mightily in recent weeks.

The Falcons, led by Bijan Robinson, should handle the Panthers easily. The Buccaneers, looking to secure their spot, face a Saints team with many backups. The Cowboys could give the Commanders a run for their money, while the Broncos might surprise with their backups against the Chiefs.

The Colts should win against the struggling Jaguars. The Texans could upset the Titans, who have been terrible against the spread. The Dolphins face a Jets team that seems to have given up, making this game a likely win for Miami. The Bills might rest starters, but they're still favorites against the Patriots.

The Chargers could win big against the Raiders, who are rated low in DVOA. The Seahawks, playing for a bonus, should handle the Rams easily. Finally, the Vikings, with a solid defense, could beat the Lions in a potential playoff preview.

What to Expect: NFL Week 18 Predictions

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