Cas12a Sensor Detects DNA Damage in One Step
The new sensor uses a single CRISPR enzyme, Cas12a, to spot damaged DNA without extra steps. A specially designed double‑stranded DNA keeps Cas12a quiet until the enzyme uracil‑DNA glycosylase (UDG) removes a uracil base. When UDG cuts the uracil out, the balance of the DNA changes and Cas12a